Hypocretin Pathology in Human Narcolepsy
نویسندگان
چکیده
منابع مشابه
[Hypocretins: involvement in the regulation of sleep-wakefulness cycle and pathogenesis of narcolepsy].
Hypocretins (also called orexins) are two newly discovered neuropeptides originating from the same precursor, preprohypocretin. The amino-acid sequences of hypocretin are highly conserved among vertebrates. Cells bodies of hypocretin neurons are restricted mainly to the lateral and ventral hypothalamus, while hypocretin fibers project throughout the brain, including several areas implicated in ...
متن کاملHypocretin deficiency develops during onset of human narcolepsy with cataplexy.
STUDY OBJECTIVES Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. SETTING Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. PATIENT AND RESULTS Two weeks after his second Pandemrix-vacc...
متن کاملIGFBP3 Colocalizes with and Regulates Hypocretin (Orexin)
BACKGROUND The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides. Based on the tight association with HLA, narcolepsy is believed to result from an autoimmune attack, but the cause of hypocretin cell loss is still unknown. We performed gene expression profiling in the hypothalamus to identify novel genes dysregulated in narcolepsy...
متن کاملRECENT CSF AND POSTMORTEM BRAIN HYPOCRETIN MEASUREMENTS IN HUMAN NARCOLEPSY SUGGEST THAT HYPOCRETIN DEFICIENCY IS INVOLVED IN THE PATHOPHYSIOLOGY OF THE DISEASE.1,2 Extended studies
RECENT CSF AND POSTMORTEM BRAIN HYPOCRETIN MEASUREMENTS IN HUMAN NARCOLEPSY SUGGEST THAT HYPOCRETIN DEFICIENCY IS INVOLVED IN THE PATHOPHYSIOLOGY OF THE DISEASE.1,2 Extended studies in idiopathic and symptomatic narcolepsy, as well as in various neurological conditions, suggest that CSF hypocretin-1 measures could be used as a diagnostic tool for narcolepsy.3,4 Although the levels in selected h...
متن کاملNarp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy.
OBJECTIVE To investigate whether neuronal activity-regulated pentraxin (Narp) colocalizes with hypocretin (Hcrt or orexin) in the normal human brain and to determine if Narp staining is lost in the narcoleptic human brain. BACKGROUND Human narcolepsy is characterized by a loss of the peptide hypocretin in the hypothalamus. This loss could result from the degeneration of neurons containing hyp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007